Estimation of Obestatin Levels and Liver and Kidney Functions in Pregnant Women with Preeclampsia Compared to Healthy Pregnant Women in Samarra City

Abstract

Background: Preeclampsia is one of the pregnancy disorders that appear after the 20th week
and is characterized by high blood pressure and protein in the urine.
Objective: The study aimed to evaluate the level of obestatin and liver function in women with
sepsis and compare it with healthy pregnant women.
Methods: A cross-sectional comparative study was conducted on 90 pregnant women, 45 with
normal blood pressure (control group) and 45 with preeclampsia during the second and third
trimester of pregnancy.
Results: There were no significant differences in the level of obestatin between women with preeclampsia and healthy pregnant women, as the median value for those with preeclampsia was
92.205 pg/mL (51.832–129.429), compared to 92.205 pg/mL (59.369–128.889) in the healthy
group, with P = 0.773. Additionally, no significant differences were observed in the levels of
total protein and albumin, with respective mean values of 7.730±1.968 g/dL and 2.713±0.888
g/dL in the preeclampsia group, compared to 7.714±1.982 g/dL and 2.865±0.976 g/dL in the
healthy group. Similarly, there were no significant differences in creatinine levels, with median
values of 1.532±1.174 mg/dL versus 1.451±0.891 mg/dL. An increase in the level of urea in
pregnant women with preeclampsia, compared to healthy pregnant women was 13.136±3.392
mg/dL versus 9.435±3.741 mg/dL, with a statistical significance P < 0.0001*. An increase in the
level of uric acid in pregnant women with preeclampsia, compared to healthy pregnant women
was 5.856±1.552 mg/dL versus 4.097±1.538 mg/dL, with statistical significance P < 0.0001*.
The area under the curve (AUC) for obestatin was 0.516 and the sensitivity was 22.22. The liver
function AUC was 0.553 and 0.543 and the sensitivity was 55.56 and 42.22. The kidney function
AUC was 0.778, 0.797, and 0.526, and the sensitivity was 77.78, 37.78, and 68.89.
Conclusion: There were no significant differences in the level of obestatin between the two
groups. No significant differences in the level of liver function, and an increase in the level of
urea and uric acid in women with preeclampsia were observed. Obestatin and liver function
tests are not diagnostic indicators for preeclampsia; However, urea and uric acid are diagnostic
indicators for preeclampsia.