The relationship between thyroid hormones and lipid profile in subclinical hypothyroidism female patients

Authors

  • Kazheen H. Jawzal Department of Chemistry, Faculty of Science, University of Zakho, Zakho, Iraq
  • Mohammed A. Hami Department of Chemistry, Faculty of Science, University of Zakho, Zakho, Iraq
  • Lina Y. Mohammed Department of Biomedical Science, College of Medicine, University of Zakho, Zakho, Iraq
  • Aveen A. Ibrahiem Department of Chemistry, Faculty of Science, University of Zakho, Zakho, Iraq

DOI:

https://doi.org/10.47419/bjbabs.v3i03.137

Keywords:

dyslipidaemia, lipid profile, subclinical hypothyroidism, thyroid hormones, TSH

Abstract

Background and objectives: Subclinical thyroid disorder is a most common subclinical disease among many medical conditions such as cardiovascular disease and subclinical Lyme disease. The aim of this study was to determine the relationship between lipid profile results, lipid ratios, and anthropometric parameters and thyroid hormones.

Methods: One hundred patients (ages 20 to 50 years) with subclinical hypothyroidism (SHT group) and 50 healthy subjects (control group), who are age-matched with patients, were included in the current study. Thyroid function tests (TSH, T3 and T4) were determined by immunodiagnostic assay system (VIDAS) for all participants. The serum glucose and lipid profile tests parameters were evaluated by Biolis 24i Premium chemistry analyser. In addition, systolic and diastolic blood pressure were measured for each individual in the study using mercury sphygmomanometer.

Results: The levels of high-density lipoprotein-cholesterol (HDL-c) were significantly lower in the SHT group when compared with control group. Whereas, the level of low-density lipoprotein-cholesterol (LDL-c), the ratios total cholesterol (TC)/HDL-c and LDL-c/HDL-c were significantly higher in SHT group than in controls. Moreover, TSH was negatively correlated with diastolic blood pressure.

Conclusions: Both LDL-c and HDL-c are altered in subclinical hypothyroidism patients. And, there is a negative association between TSH and diastolic blood pressure.

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References

Ç Kaplan and F Erdog˘an. “Effect of dietary propolis on growth, body composition, and serum biochemistry of juvenile sea bream (Sparus aurata)”. Aquacult Int 29 (2021), pp. 553–563. DOI: 10.1007/s10499-020-00642-w. DOI: https://doi.org/10.1007/s10499-020-00642-w

E N Pearce. “Update in lipid alterations in subclinical hypothyroidism”. J Clin Endocrinol Metab 97(2) (2012), pp. 326–333. DOI: 10.1210/jc.2011-2532. DOI: https://doi.org/10.1210/jc.2011-2532

E Pucci, L Chiovato, and A Pinchera. “Thyroid and lipid metabolism”. Int J Obes 24(2) (2000), pp. 109–112. DOI: 10.1038/sj.ijo.0801292. DOI: https://doi.org/10.1038/sj.ijo.0801292

F Y Tseng, W Y Lin, and C C Lin. “Subclinical hypothyroidism is associated with increased risk for all-cause and cardiovascular mortality in adults”. J Am Coll Cardiol 60(8) (2012), pp. 730–737. DOI: 10.1016/j.jacc.2012.03.047. DOI: https://doi.org/10.1016/j.jacc.2012.03.047

G Brenta. “Why can insulin resistance be a natural consequence of thyroid dysfunction”. J Thyroid Res (2011), pp. 152850–152850. DOI: 10.4061/2011/152850. DOI: https://doi.org/10.4061/2011/152850

G J Canaris et al. “The Colorado thyroid disease prevalence study”. Arch Intern Med 160(4) (2000), pp. 526–534. DOI: 10.1001/archinte.160.4.526. DOI: https://doi.org/10.1001/archinte.160.4.526

General Assembly of the World Medical Association. “World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects”. J Am Coll Dent 81(3) (2014), pp. 14–18.

H Liu and D Peng. “Update on dyslipidemia in hypothyroidism: the mechanism of dyslipidemia in hypothyroidism”. Endocr Connect 11 (2022), e210002–e210002. DOI: 10.1530/EC-21-0002. DOI: https://doi.org/10.1530/EC-21-0002

H Vierhapper et al. “Low-density lipoprotein cholesterol in subclinical hypothyroidism”. Thyroid 10(11) (2000), pp. 981–984. DOI: https://doi.org/10.1089/thy.2000.10.981

J J Staub, B U Althaus, H Engler, et al. “Spectrum of subclinical and overt hypothyroidism: effect on thyrotropin, prolactin, and thyroid reserve, and metabolic impact on peripheral target tissues”. Am J Med 92(6) (1992), pp. 631–642. DOI: 10.1016/0002-9343(92)90782-7. DOI: https://doi.org/10.1016/0002-9343(92)90782-7

J Kvetny et al. “Subclinical hypothyroidism is associated with a low-grade inflammation, increased triglyceride levels and predicts cardiovascular disease in males below 50 years”. Clin Endocrinol (Oxf) 61(2) (2004), pp. 232–238. DOI: 10.1111/j.1365-2265.2004.02088.x. DOI: https://doi.org/10.1111/j.1365-2265.2004.02088.x

K Hashimoto. “Update on subclinical thyroid dysfunction”. Endocr J 69(7) (2022), pp. 725–738. DOI: 10.1507/endocrj.EJ22-0182. DOI: https://doi.org/10.1507/endocrj.EJ22-0182

K Loh, S Tam, L Murray-Segal, et al. “Inhibition of adenosine monophosphate-activated protein kinase-3-hydroxy-3-methylglutaryl coenzyme A reductase signaling leads to hypercholesterolemia and promotes hepatic steatosis and insulin resistance”. Hepatol Commun 3(1) (2018), pp. 84–98. DOI: 10.1002/hep4.1279. DOI: https://doi.org/10.1002/hep4.1279

K Sukhu et al. “Comparison of an immuno-turbidometric method (STalia D-DI) with an established enzyme linked fluorescent assay (VIDAS) D-dimer for the exclusion of venous thromboembolism”. Int J Lab Hematol 30(3) (2008), pp. 200–204. DOI: 10.1111/j.1751-553X.2007.00942.x. DOI: https://doi.org/10.1111/j.1751-553X.2007.00942.x

K Zha, C Zuo, and A Wang. “LDL in patients with subclinical hypothyroidism shows increased lipid peroxidation”. Lipids Health Dis 14 (2015), pp. 95–95. DOI: 10.1186/s12944-015-0092-4. DOI: https://doi.org/10.1186/s12944-015-0092-4

L H Duntas and G Brenta. “A renewed focus on the association between thyroid hormones and lipid metabolism”. Front Endocrinol 9 (2018), pp. 511–511. DOI: 10.3389/fendo.2018.00511. DOI: https://doi.org/10.3389/fendo.2018.00511

M A Ganie, B A Laway, and T A Wani. “Association of subclinical hypothyroidism and phenotype, insulin resistance, and lipid parameters in young women with polycystic ovary syndrome”. Fertil Steril 95(6) (2011), pp. 2039–2043. DOI: 10.1016/j.fertnstert.2011.01.149. DOI: https://doi.org/10.1016/j.fertnstert.2011.01.149

M A Hami, Y A Al-Tamer, and O M Al-Hebib. “The association between selected elements and body mass index and age in male subjects ”. Trace Elem Electroly 37(3) (2020), pp. 139–144. DOI: 10.5414/TEX01613. DOI: https://doi.org/10.5414/TEX01613

M Cheserek et al. “Evaluation of the relationship between subclinical hypothyroidism and metabolic syndrome components among workers”. Int J Occup Med Environ Health 27(2) (2014), pp. 175–187. DOI: 10.2478/s13382-014-0240-5. DOI: https://doi.org/10.2478/s13382-014-0240-5

M Ito, T Arishima, and T Kudo. “Effect of levo-thyroxine replacement on non-high-density lipoprotein cholesterol in hypothyroid patients”. J Clin Endocrinol Metab 92(2) (2007), pp. 608–611. DOI: 10.1210/jc.2006-1605. DOI: https://doi.org/10.1210/jc.2006-1605

M M Pesic et al. “Subclinical hypothyroidism: association with cardiovascular risk factors and components of metabolic syndrome”. Biotechnol Biotechnol Equip 29(1) (2015), pp. 157–163. DOI: 10.1080/13102818.2014.991136. DOI: https://doi.org/10.1080/13102818.2014.991136

M Peppa, G Betsi, and G Dimitriadis. “Lipid abnormalities and cardiometabolic risk in patients with overt and subclinical thyroid disease”. J Lipids (2011), pp. 575840–575840. DOI: 10.1155/2011/575840. DOI: https://doi.org/10.1155/2011/575840

N Caraccio, E Ferrannini, and F Monzani. “Lipoprotein profile in subclinical hypothyroidism: response to levothyroxine replacement, a randomized

N Karthick et al. “Dyslipidaemic changes in women with subclinical hypothyroidism”. J Clin Diagn Res 7(10) (2013), pp. 2122–2125. DOI: 10.7860/JCDR/2013/5777.3448. DOI: https://doi.org/10.7860/JCDR/2013/5777.3448

N Knudsen, P Laurberg, and L B Rasmussen. “Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population”. J Clin Endocrinol Metab 90(7) (2005), pp. 4019–4024. DOI: 10.1210/jc.2004-2225. DOI: https://doi.org/10.1210/jc.2004-2225

N Maleki et al. “Assessment of cardiovascular risk factors in patients with subclinical hypothyroidism”. Acta Cardiol 71(6) (2016), pp. 691–697. DOI: 10.2143/AC.71.6.3178188. DOI: https://doi.org/10.1080/AC.71.6.3178188

P N Taylor, D Albrecht, and A Scholz. “Global epidemiology of hyperthyroidism and hypothyroidism”. Nat Rev Endocrinol 14(5) (2018), pp. 301–316. DOI: 10.1038/nrendo.2018.18. DOI: https://doi.org/10.1038/nrendo.2018.18

P P Toth. “Subclinical atherosclerosis: what it is, what it means and what we can do about it”. Int J Clin Pract 62(8) (2008), pp. 1246–54. DOI: 10.1111/j.1742-1241.2008.01804.x. DOI: https://doi.org/10.1111/j.1742-1241.2008.01804.x

placebo-controlled study”. J Clin Endocrinol Metab 87(4) (2002), pp. 1533–1538. DOI: 10.1210/jcem.87.4.8378. DOI: https://doi.org/10.1210/jcem.87.4.8378

S H Khan, N Fazal, A Ijaz, et al. “Insulin resistance and glucose levels in subjects with subclinical hypothyroidism”. J Coll Physicians Surg Pak 27(6) (2017), pp. 329–333.

S Vyakaranam et al. “Study of Insulin Resistance in Subclinical Hypothyroidism”. Int J Health Sci Res 4(9) (2014), pp. 147–153.

Thomas Lathrop Stedman. Stedman’s Medical Dictionary for the Health Professions and Nursing. Philadelphia, USA: Lippincott Williams & Wilkins, 2005.

X Huang, X Zhang, X Zhou, et al. “Prevalence of thyroid dysfunction in a Chinese population with different glucose intolerance status: A community-based cross-sectional study”. Diabetes Metab Syndr Obes 13 (2020), pp. 4361–4368. DOI: 10.2147/DMSO.S271328. DOI: https://doi.org/10.2147/DMSO.S271328

Z Efstathiadou, S Bitsis, H J Milionis, et al. “Lipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial?” Eur J Endocrinol 145(6) (2001), pp. 705–710. DOI: 10.1530/eje.0.1450705. DOI: https://doi.org/10.1530/eje.0.1450705

GA-137-2022

Published

16-09-2022

How to Cite

The relationship between thyroid hormones and lipid profile in subclinical hypothyroidism female patients. (2022). Baghdad Journal of Biochemistry and Applied Biological Sciences, 3(03), 200-209. https://doi.org/10.47419/bjbabs.v3i03.137

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