The antioxidant, antimicrobial, and clinical effects with elemental contents of pomegranate (Punica granatum) peel extracts: A review

Abdul Qahir; Attiq-Ur-Rehman Kakar; Naqeebullah Khan; Samiullah; Abdul Hakeem; Rehana Kamal; Fazal-Ur-Rehman

doi:10.47419/bjbabs.v2i01.33

Authors

Abdul Qahir Higher and Technical Education Department, Balochistan, Quetta 87300, Pakistan
Attiq-Ur-Rehman Kakar Higher and Technical Education Department, Balochistan, Quetta 87300, Pakistan
Naqeebullah Khan Higher and Technical Education Department, Balochistan, Quetta 87300, Pakistan
Samiullah Higher and Technical Education Department, Balochistan, Quetta 87300, Pakistan
Abdul Hakeem Higher and Technical Education Department, Balochistan, Quetta 87300, Pakistan
Rehana Kamal Department of Obstetrics and Gynecology, Bolan University of Medical and Health Sciences, Quetta 87300-Pakistan
Fazal-Ur-Rehman Faculty of Life Sciences, Department of Microbiology, University of Balochistan, Quetta 87300-Pakistan

DOI:

https://doi.org/10.47419/bjbabs.v2i01.33

Keywords:

antimicrobial activity, antioxidant, clinical activity, peel, pomegranate

Abstract

Pomegranate belongs to the family of Punicaceae. It has deciduous shrubs. Pomegranate is generally cultivated in Afghanistan, China, Iran, India, Pakistan, USA. This study aimed to review the pomegranate peels for exploring their importance in the field of health. This review showed that Pomegranate is used as food and plays a vital role in the medicinal field. Because pomegranate fruit and its peel extraction contain various compounds like antioxidants, phenolic Acid, flavonoids, tannins etc., that have been found very effective in the health field. Due to the presence of antioxidants and other active compounds, pomegranates' peel is imperative for the betterment of human health. Besides, various medicines, such as antidiarrheal medicines, may be prepared from the peel extract of Pomegranate. Peel extract can act against various microbes such as Klebsiella pneumonia and Staphylococcus epidermidis, Bacillus subtilis, Klebsiella pneumoniae, Salmonella typhi, E. coli, S. aureus etc. The pomegranate strip and root have been accounted for in creatures to diminish blood glucose activity. It concludes that further research is needed to explore the hidden characteristics of pomegranate peel.

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References

A B Howell and Doris H D’Souza. “The pomegranate: Effects on bacteria and viruses that influence human health”. Evid Based Complement Alternat Med 2013(606212) (2013), pp. 1–11. DOI: 10.1155/2013/606212. DOI: https://doi.org/10.1155/2013/606212

A. D. Alanís et al. “Antibacterial properties of some plants used in Mexican traditional medicine for the treatment of gastrointestinal disorders”. J Ethnopharmacol 100(1-2) (2005), pp. 153–157. DOI: 10.1016/j.jep.2005.02.022. DOI: https://doi.org/10.1016/j.jep.2005.02.022

B Singh et al. “Phenolic composition and antioxidant potential of grain legume seeds: A review”. Food Res Int 101 (2017), pp. 1–16. DOI: 10.1016/j.foodres.2017.09.026. DOI: https://doi.org/10.1016/j.foodres.2017.09.026

Bassam Alagy. Soil Pollution, Pesticide. Ed. by and others. Vol. 1. 2015, p. 77.

D. Prashanth, M. K. Asha, and A. Amit. “Antibacterial activity of Punica granatum”. Fitoterapia 72(2) (2001), pp. 171–173. DOI: 10.1016/s0367-326x(00)00270-7. DOI: https://doi.org/10.1016/S0367-326X(00)00270-7

Eliana Harue Endo et al. “Activity of spray-dried microparticles containing pomegranate peel extract against Candida albicans”. Molecules 17(9) (2012), pp. 10094–10107. DOI: 10.3390/molecules170910094. DOI: https://doi.org/10.3390/molecules170910094

Erin M McCarrell et al. “Antimicrobial activities of pomegranate rind extracts: enhancement by addition of metal salts and vitamin C”. BMC Complemen Altern Med 8(1) (2008), p. 64. DOI: 10.1186/1472-6882-8-64. DOI: https://doi.org/10.1186/1472-6882-8-64

F Tang. Metabolic profiling of complex mixtures using novel NMR-based approaches and chemometrics: Pomegranate juice as a case study. Doctoral dissertation. The Ohio State University, 2020.

Fahad bin Nasser Eid Al- Subaie, Muhammad ibn Abd Al-Rahman, and Hani bin Menem Shamshary. Examining the canned food contamination with elements of heavy metals, nitrates and nitrites. p. 89. 2014.

FAO/WHO. “Joint FAO/WHO food standers program, codes Aliment Arius commission contamination.” In: vol. XV. 11. FAO, Roma CAC, 1984, p. 56.

G F Ferrazzano et al. “In vitro antibacterial activity of pomegranate juice and peel extracts on cariogenic bacteria”. BioMed Res Int 2017 (2017), p. 2152749. DOI: 10.1155/2017/2152749. DOI: https://doi.org/10.1155/2017/2152749

G Jelodar, M Mohsen, and S Shahram. “Effect of walnut leaf, coriander and pomegranate on blood glucose and histopathology of pancreas of alloxan induced diabetic rats”. Afr J Tradit Complement Altern Med 4(3) (2008), pp. 299–305. DOI: 10.4314/ajtcam.v4i3.31223. DOI: https://doi.org/10.4314/ajtcam.v4i3.31223

I Kahramanoglu and S Usanmaz. Pomegranate Production and Marketing. CRC Press, 2016. DOI: https://doi.org/10.1201/b20151

J Gadže et al. “Physico-chemical characteristics of main pomegranate (Punica granatum L.) cultivars grown in Dalmatia region of Croatia”. J Appl Bot Food Qual 85(2) (2013), p. 202.

L H Ibraheen and S A Abed. “Accumulation detection of some heavy metals in some types of fruits in the local market of Al-Diwaniyah City, Iraq”. Rasayan J Chem 10(2) (2017), pp. 339–343. DOI: 10.7324/RJC.2017.1021641. DOI: https://doi.org/10.7324/RJC.2017.1021641

L. C. Braga et al. “Pomegranate extract inhibits Staphylococcus aureus growth and subsequent enterotoxin production”. J Ethnopharmacol 96(1-2) (2005), pp. 335–339. DOI: 10.1016/j.jep.2004.08.034. DOI: https://doi.org/10.1016/j.jep.2004.08.034

Lisbeth A. Pacheco-Palencia et al. “Protective effects of standardized pomegranate (Punica granatum L.) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts”. J Agric Food Chem 56(18) (2008), pp. 8434–8441. DOI: 10.1021/jf8005307. DOI: https://doi.org/10.1021/jf8005307

M. Viuda-Martos, J. Fernández-López, and J. A. Pérez-Álvarez. “Pomegranate and its many functional components as related to human health: A review”. Compr Rev Food Sci Food Saf 9(6) (2010), pp. 635–654. DOI: 10.1111/j.1541-4337.2010.00131.x. DOI: https://doi.org/10.1111/j.1541-4337.2010.00131.x

Mouna Abid et al. “Antioxidant properties and phenolic profile characterization by LC–MS/MS of selected Tunisian pomegranate peels”. J Food Sci Tech 54(9) (2017), pp. 2890–2901. DOI: 10.1007/s13197-017-2727-0. DOI: https://doi.org/10.1007/s13197-017-2727-0

Muhammad Rahim et al. “Analysis of toxic heavy metal content of the most widely consumed fruits”. J Phys Sci 31(2) (2020), pp. 61–73. DOI: 10.21315/jps2020.31.2.5. DOI: https://doi.org/10.21315/jps2020.31.2.5

O A Fawole, N P Makunga, and U L Opara. “antioxidant and tyrosinase-inhibition activities of pomegranate fruit peel methanolic extract”. BMC Complement Altern Med 12 (2012), p. 200. DOI: 10.1186/1472-6882-12-200. DOI: https://doi.org/10.1186/1472-6882-12-200

P Yasoubi et al. “Total phenolic contents and antioxidant activity of Pomegranate (Punica granatum L.) peel extracts”. J Agri Sci Tech 9(1) (2007), pp. 34–42.

R. Wise et al. “Antimicrobial resistance”. BMJ 317(7159) (1998), pp. 609–610. DOI: 10.1136/bmj.317.7159.609. DOI: https://doi.org/10.1136/bmj.317.7159.609

S R Kanatt, R Chander, and A Sharma. “Antioxidant and antimicrobial activity of pomegranate peel extract improves the shelf life of chicken products”. Int J Food Sci Tech 45 (2016), pp. 216–222. DOI: 10.1111/j.1365-2621.2009.02124.x. DOI: https://doi.org/10.1111/j.1365-2621.2009.02124.x

Sadiye Gözlekçi et al. “Total phenolic distribution of juice, peel, and seed extracts of four pomegranate cultivars”. Pharmacogn Mag 7(26) (2011), p. 161. DOI: 10.4103/0973-1296.80681. DOI: https://doi.org/10.4103/0973-1296.80681

Saeed Akhtar et al. “Pomegranate peel and peel extracts: Chemistry and food features”. Food Chem 174 (2015), pp. 417–425. DOI: 10.1016/j.foodchem.2014.11.035. DOI: https://doi.org/10.1016/j.foodchem.2014.11.035

T P Devasagayam et al. “Free radicals and antioxidants in human health: current status and future prospects”. J Assoc Physicians India 52 (2004), pp. 794–804.

Yeshvandra Verma and S. V. S. Rana. “Assessment of cadmium, chromium, and copper levels in market fruit samples in Meerut, North India”. Toxicol Environ Chem 96(10) (2014), pp. 1516–1522. DOI: 10.1080/02772248.2015.1029735. DOI: https://doi.org/10.1080/02772248.2015.1029735

Zahra Amri et al. “Phytochemical content, Fatty acids composition and antioxidant potential of different pomegranate parts: Comparison between edible and non edible varieties grown in Tunisia”. Int J Biol Macromol 104 (2017), pp. 274–280. DOI: 10.1016/j.ijbiomac.2017.06.022. DOI: https://doi.org/10.1016/j.ijbiomac.2017.06.022

Zahra Derakhshan et al. “Antioxidant activity and total phenolic content of ethanolic extract of pomegranate peels, juice and seeds”. Food Chem Toxicol 114 (2018), pp. 108–111. DOI: 10.1016/j.fct.2018.02.023. DOI: https://doi.org/10.1016/j.fct.2018.02.023