FOXA1 expression in Iraqi women with ER+ breast cancer
Keywords:breast cancer, ER , FOXA1, immunohistochemistry, RT-qPCR
Background: Breast cancer (BC) is a heterogeneous disease that can be classified into many subtypes according to histopathological and molecular characteristics. Forkhead box protein A1 (FOXA1) is a pioneer factor of estrogen receptor (α-ER)-chromatin binding and function. FOXA1 expression is related to luminal BC with a good prognosis.
Objectives: The present study is sought to determine the FOXA1 expression in Iraqi women with ER+ BC from fresh tissue.
Methods: Forty-eight fresh malignant breast tissues were analyzed by immunohistochemistry assay to choose ER+ samples, and then by RT-qPCR to evaluate FOXA1 gene expression.
Results: The ER-positive samples were (72.91%) of the total samples, luminal A was the most common molecular subtype with (56.25%).
Conclusions: Highly significant FOXA1 expression was found in Iraqi women with BC makes it eligible to be a good predictor or a biomarker for BC.
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Copyright (c) 2021 Iman Hatif Al-Bedairy, Mais Shamsa, Safaa aldeen Salim, Mohammed Mahdi, Karam Dawood, Abdul Hussein M. Al Faisal
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