The correlation of vitamin D with HOMA-IR and glycated hemoglobin in type 2 diabetes mellitus patients


  • Sujesh-Kumar Narayanan Department of Biochemistry, Sree Uthradom Thirunal (SUT) Academy of Medical Sciences, Trivandrum, Kerala, India
  • Renjith Gopikuttan Department of Biochemistry, Sree Uthradom Thirunal (SUT) Academy of Medical Sciences, Trivandrum, Kerala, India



HOMA-IR, HbA1c, type 2 diabetes mellitus, vitamin D


Background and objective: Vitamin D’s primary functions are the homeostasis of calcium and bone metabolism, but it also has a significant role in the homeostasis of plasma glucose. This study sought to examine the relationship between vitamin D and glycated hemoglobin and insulin resistance in type 2 diabetes mellitus (T2DM).

Methods: A total of 150 patients with newly diagnosed T2DM participated in this case-control study. Additionally, 150 controls of the same age and gender were also recruited. Serum vitamin D and fasting insulin levels were estimated by the electrochemiluminescence immunoassay (ECLIA) method. And, high-performance liquid chromatography (HPLC) was used to analyze HbA1c. Pearson’s correlation coefficient was used to determine the association of vitamin D with HbA1c and HOMA-IR.

Results: About 71% of diabetes patients had low vitamin D levels, compared to 31% in the control group. Vitamin D-deficient T2DM subjects had significantly higher HOMA-IR and HbA1c levels. In addition, a strong negative association between vitamin D and HOMA-IR (r = -0.75) and vitamin D and HbA1c (r = -0.73) has been demonstrated among T2DM patients.

Conclusions: Vitamin D deficiency is correlated with ineffective glycemic control, and the reason might be its potential role in the secretion and sensitivity of insulin. Therefore, vitamin D screening must be incorporated as a routine check-up for T2DM patients.


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How to Cite

Narayanan, S.-K., & Gopikuttan, R. (2022). The correlation of vitamin D with HOMA-IR and glycated hemoglobin in type 2 diabetes mellitus patients. Baghdad Journal of Biochemistry and Applied Biological Sciences, 3(04), 273–285.